Like Arsenal on Saturday, Manchester United will be shifting their focus back to the Premier League this weekend as Tottenham Hotspur visit Old Trafford in a game that could yet prove vital for both teams’ aspirations of qualifying for the Champions League this season.

Unlike Arsenal and their game against West Ham, however, this is one top flight fixture that has seen a dramatic shift in power in recent Premier League campaigns as, following a run of 17 wins and no defeats in 22 matches, the Red Devils have now not won any of their last five meetings with Spurs.

Such a sequence means that Tottenham have become only the third team in the Premier League era to go five games unbeaten against United, and Mauricio Pochettino’s men will be looking to extend that streak against a side who have nevertheless won 11 of their last 13 ties at Old Trafford this season.

Although such statistics enable us to make a case for either side here, the bookmakers are backing Louis van Gaal’s team to emerge victorious from this one and have named United as 17/20 favourites for the game, with Tottenham out at 18/5 and the draw coming in at a best-priced 14/5.

Given United have lost their last two home games against Spurs in the Premier League, you’d be wise to treat odds-on prices for a home win with a degree of caution and may actually find more joy in one of the other markets. Tottenham, for example, have taken more points from a losing position (16) than any other Premier League side this season and you can get 19/4 on them to come from behind and win or draw the game should the Red Devils again open the scoring in front of their fans.

As Spurs have conceded in 11 of their previous 12 away matches, it looks unlikely that they’ll be able to keep United at bay here even if they do go on to get something from the game – and you can find odds of 7/1 on the match either finishing 1-1 or on both teams scoring in an eventual Tottenham win.

Chief to United’s chances of scoring will be Wayne Rooney, who has now been restored to his preferred position up front and has bagged a whopping seven goals in his last eight Premier League starts against Tottenham. Given the England man is only 9/2 to score first, however, you might prefer to take longer odds of 7/1 on Rooney scoring two or more if you fancy the home team here.

For Tottenham, meanwhile, local hero Harry Kane has now scored in his last six Premier League away games and will be looking to become only the second ever player to extend that streak to seven matches. The in-form striker is 6/1 to do so as the game’s first goalscorer and 21/10 to score at any point in the match, with the recent improvement in Andros Townsend’s performances over the past couple of games also making him an attractive outside bet at big odds of 16/1.